The top 100 biotech VCs

April 28, 2023



After a decade-long boom, venture investment in biopharma has crashed to levels not seen since 2016.

But there are still some VCs investing in new biotech startups. Below is a list of the 100 biotech investors who are most active today, despite challenging markets.

The list includes the following info to help you target the right investors (items in bold are only available in the paid version of the spreadsheet):

The spreadsheet covers Series A and later rounds, so is not as useful for pre-seed and seed investors. We do not provide contact info. Cold emailing / mass emailing investors does not work 99% of the time.

The best way to get in touch with investors is getting a high quality referral from a founder they've already invested in (and ideally, a founder who's made that investor money). It takes a lot of work to build these relationships and get good intros, but if you don't do this work, it is very difficult to raise in this market.

The full list of the top 1,500 biotech investors

Download a spreadsheet with over 1,500 biotech investors, including hard-to-find data like check size, zombie rate, and "aggressiveness ratio".





The top 100 biotech VCs


Updated April 27, 2023 Lead investments New non-lead investments Follow-ons in existing portfolio
Investor name Investor strategy Top geographies (% of investments per location) Last 6 months Since 2018 % change in # inv, last 6 mo. Last 6 months Since 2018 Last 6 months Recent investments
ARCH Venture PartnersSeries A LeadCambridge: 27%, San Diego: 16%, South San Francisco: 10%64020%2522Orbital Therapeutics, Volastra Therapeutics, Rapport Therapeutics, Chroma Medicine, Aera Therapeutics
VersantSeries A LeadSan Diego: 18%, Basel: 8%, Cambridge: 7%534400%0363Abdera Therapeutics, Santa Ana Bio, LENZ Therapeutics, Belharra Therapeutics, Launchpad Therapeutics
Pfizer Venture InvestmentsSeries B Follow-onCambridge: 18%, Waltham: 7%, Cambridge, UK: 7%417300%2371Flare Therapeutics, Mediar Therapeutics, Ribon Therapeutics, Grey Wolf Therapeutics, Mediar Therapeutics
General CatalystSeed LeadPalo Alto: 18%, San Francisco: 18%, San Diego: 18%470%0100CTRL Therapeutics, ArriVent Biopharma, Faro Health, Vial, Odyssey Therapeutics
SofinnovaSeries A LeadCambridge: 18%, Boston, MA: 6%, Basel: 6%330200%1402ArriVent Biopharma, Mediar Therapeutics, Noema Pharma, Chroma Medicine, Amolyt Pharma
GVSeries A Follow-onSouth San Francisco: 15%, Cambridge: 14%, Boston: 10%32050%1552EpiBiologics, Santa Ana Bio, Chroma Medicine, Aera Therapeutics, Cerevance
RA Capital ManagementSeries B LeadSan Diego: 10%, Cambridge: 10%, Boston: 7%360-63%51154Alentis Therapeutics, Capacity Bio, LENZ Therapeutics, Bicara Therapeutics, Hemab
OrbimedSeries A LeadSan Diego: 12%, South San Francisco: 9%, Boston: 7%344-25%3826Aer Therapeutics, ArriVent Biopharma, Garuda Therapeutics, ADARx Pharmaceuticals, Pathalys Pharma
Jeito CapitalSeries A LeadLondon: 20%, Basel: 20%, Paris: 13%311-25%1130Alentis Therapeutics, Noema Pharma, CatalYm, HI-Bio, SparingVision
Qiming Venture PartnersSeries A LeadShanghai: 14%, Suzhou: 10%, Cambridge: 7%31450%1251Abdera Therapeutics, Allorion Therapeutics, TandemAI, Oricell, Entact Bio
Perceptive XontogenySeries A LeadColumbus: 22%, Philadelphia: 22%, Los Angeles: 11%35200%280TORL BioTherapeutics, CARGO Therapeutics, Tellus Therapeutics, Peroxitech, Apogee Therapeutics
RTW InvestmentsSeries B LeadSeattle: 7%, Cambridge, MA: 7%, San Diego: 5%3160%1371Abdera Therapeutics, LENZ Therapeutics, CARGO Therapeutics, Oricell, Apogee Therapeutics
FlagshipSeries A LeadCambridge: 79%, Cambridge, MA: 5%, Boston: 5%2170%0181Ring Therapeutics, Ampersand Biomedicines, Montai Health, Cellarity, Apriori Bio
SanofiSeries B LeadCambridge: 26%, Copenhagen: 10%, San Diego: 10%212100%2251QurAlis, Avilar Therapeutics, NextPoint Therapeutics, Nextpoint Therapeutics, MinervaX
WellingtonSeries B Follow-onCambridge: 14%, San Diego: 8%, South San Francisco: 7%218100%2463Seamless Therapeutics, Chroma Medicine, CARGO Therapeutics, MinervaX, Apogee Therapeutics
PolarisSeries A LeadCambridge: 18%, Boston: 10%, South San Francisco: 10%2140%0223EpiBiologics, Volastra Therapeutics, Noema Pharma, Faro Health, Jnana Therapeutics
The Column GroupSeries A LeadCambridge: 22%, Menlo Park: 12%, San Diego: 10%2160%0182Hexagon Bio, Synthekine, Cajal Neuroscience, Casma Therapeutics, Carmot Therapeutics
Bain Capital Life SciencesSeries B Follow-onCambridge: 16%, Boston: 9%, San Diego: 9%211100%0250Jnana Therapeutics, Emalex Biosciences, Rivus Pharmaceuticals, Nimbus Therapeutics, Areteia Therapeutics
NovoSeries B LeadCopenhagen: 8%, Cambridge: 6%, South San Francisco: 6%223100%1343Alentis Therapeutics, Adcendo, Hemab, Amolyt Pharma, Metagenomi
MPM CapitalSeries A LeadCambridge: 44%, South San Francisco: 18%, Cambridge, MA: 12%2130%0151NextPoint Therapeutics, Nextpoint Therapeutics, Arialys Therapeutics, Photys Therapeutics, Orna Therapeutics
Third RockSeries A LeadCambridge: 55%, South San Francisco: 18%, Boston: 9%220100%0202Flare Therapeutics, Rapport Therapeutics, CARGO Therapeutics, Casma Therapeutics, Terremoto Biosciences
Mubadala VenturesSeries A Follow-onSalt Lake City, UT: 12%, Watertown: 8%, Durham: 8%26100%2180Hasten Biopharma, EpiBiologics, Chroma Medicine, Juvena Therapeutics, Neumora Therapeutics
CanaanSeries A LeadSouth San Francisco: 14%, Oxford: 10%, Seattle: 7%213100%0131Aer Therapeutics, Halda Therapeutics, Grey Wolf Therapeutics, Normunity, Rondo Therapeutics
Catalio Capital ManagementSeries A Follow-onBoston: 16%, South San Francisco: 13%, Cambridge: 13%290%5270ArriVent Biopharma, Volastra Therapeutics, NextPoint Therapeutics, Perceive Biotherapeutics, Metagenomi
Access IndustriesSeries A Follow-onCambridge: 44%, San Diego: 12%, Redmond, WA: 8%211-33%0180Hemab, Halda Therapeutics, Treeline Biosciences, Matchpoint Therapeutics, Acelyrin
New Enterprise AssociatesSeries A LeadSan Diego: 11%, Boston: 8%, Cambridge: 8%219-33%0261Launchpad Therapeutics, Nexo Therapeutics, MBX Biosciences, Code Biotherapeutics, Splice Bio
venBioSeries A LeadSan Diego: 20%, Boston: 9%, Los Angeles: 6%2170%0210Abdera Therapeutics, Entact Bio, Acelyrin, ImmPACT Bio, Ceptur Therapeutics
Arix BioscienceSeries B LeadCambridge: 38%, Cambridge, UK: 15%, Boston: 8%250%060Evommune, Ensoma, Disc Medicine, Artios Pharma, Pyxis Oncology
Westlake Village BioPartnersSeries A LeadSouth San Francisco: 47%, Thousand Oaks: 13%, Los Angeles: 13%28-33%1100Akamis Bio, Dantari, Vega Therapeutics, Acelyrin, ArsenalBio
Decheng CapitalSeries B LeadShanghai: 14%, South San Francisco: 14%, San Diego: 14%210100%0130VintaBio, CG Oncology, Acelyrin, ImmPACT Bio, Acelyrin
Avalon VenturesSeries A LeadLa Jolla: 29%, La Jolla, CA: 29%, : 29%230%031Enlaza Therapeutics, Arialys Therapeutics, Jnana Therapeutics, Jnana Therapeutics, Janux Therapeutics
Lux CapitalSeries A Follow-onSalt Lake City, UT: 15%, New York: 11%, San Francisco: 11%290%0151Aera Therapeutics, Enveda Biosciences, Cajal Neuroscience, Anagenex, Creyon Bio
Northpond VenturesSeries A LeadCambridge: 25%, Emeryville: 6%, Cambridge, MA: 6%120-80%0221Faro Health, Garuda Therapeutics, EnPlusOne Biosciences, CAMP4 Therapeutics, Code Biotherapeutics
Goldman SachsSeries B Follow-onCambridge: 20%, Los Angeles: 10%, Wellesley: 10%150%090TORL BioTherapeutics, Nested Therapeutics, MegaRobo Technologies, MOMA Therapeutics, Shanghai ZhenGe Biotech
Horizons VenturesSeries B LeadBerkeley: 27%, Boston: 20%, London: 13%170%0100Juvena Therapeutics, Carmot Therapeutics, Manifold Bio, Epic Bio, Kelonia Therapeutics
DCVCSeries A LeadSouth San Francisco: 25%, San Diego: 19%, Salt Lake City, UT: 12%113-50%1170Shennon Biotechnologies, Chroma Medicine, Novome Biotechnologies, Auron Therapeutics, Relation Therapeutics
Andreessen HorowitzSeries A LeadSouth San Francisco: 28%, Cambridge: 22%, San Carlos: 9%1130%0171Orbital Therapeutics, Function Oncology, IDRx, Vicinitas Therapeutics, CAMP4 Therapeutics
VivoSeries C Follow-onSuzhou: 8%, San Diego: 8%, South San Francisco: 8%19-50%2271EpiBiologics, Rgenta Therapeutics, Bonum Therapeutics, Zenas Biopharma, Inspirna
MedicxiSeries A LeadCambridge: 14%, Charlottesville: 9%, Foster City: 9%1120%0170Aldena Therapeutics, Rivus Pharmaceuticals, MiroBio, Versanis Bio, Rivus Pharmaceuticals
SynconaSeries A LeadLondon: 36%, New York: 7%, Cambridge: 7%17-50%080Mosaic Therapeutics, SwanBio, OMass Therapeutics, Forcefield Therapeutics, Anaveon
Panacea Healthcare VentureSeries A LeadStrasbourg: 17%, Berkeley: 17%, Cambridge: 17%140%060hC Bioscience, Domain Therapeutics, Actym Therapeutics, Oncologie, Tactiva Therapeutics
ForbionSeries A LeadNaarden: 11%, Cambridge: 9%, Munich: 6%117-75%1232Complement Therapeutics, Seamless Therapeutics, Noema Pharma, CatalYm, F2G
GimvSeries A Follow-onCambridge: 22%, Marseille: 11%, Medfield: 11%140%270Complement Therapeutics, Mediar Therapeutics, Mediar Therapeutics, ImmunOs Therapeutics, Anjarium Biosciences
LYFE CapitalSeries A LeadShanghai: 30%, San Diego: 30%, Philadelphia: 10%150%090iECURE, Aspen Neuroscience, Kyverna Therapeutics, Shanghai ZhenGe Biotech, Sciwind Biosciences
Apple Tree PartnersSeries A LeadBoston: 28%, Cambridge: 17%, New York: 11%1140%0150Aethon Therapeutics, Ascidian Therapeutics, Galvanize Therapeutics, Adendra Therapeutics, Intergalactic Therapeutics
Sectoral Asset ManagementSeries A Follow-onCambridge: 27%, Boston: 13%, Naarden: 13%130%172LENZ Therapeutics, Garuda Therapeutics, Amolyt Pharma, Apnimed, Mineralys Therapeutics
Leaps by BayerSeries A LeadCambridge: 31%, Emeryville: 10%, Boston: 7%116-83%1221NextPoint Therapeutics, Metagenomi, Nextpoint Therapeutics, Capstan Therapeutics, ReCode Therapeutics
AislingSeries B Follow-onCambridge: 15%, Boston, MA: 10%, Stamford: 10%140%0150Garuda Therapeutics, Treeline Biosciences, Forge Biologics, Antios Therapeutics, Garuda Therapeutics
Cambrian BiopharmaSeries A LeadNew York: 40%, Gaithersburg, MD: 20%, Boston: 20%140%050Amplifier Therapeutics, Oviva Therapeutics, Vita Therapeutics, Arcellx, Sensei Biotherapeutics
Section 32Series B Follow-onCambridge: 36%, San Diego: 18%, South San Francisco: 9%170%0251Function Oncology, Faro Health, Nested Therapeutics, BigHat Biosciences, Manifold Bio
Alexandria Venture InvestmentsSeries A Follow-onCambridge: 25%, New York: 10%, San Diego: 10%140%7873Orbital Therapeutics, TORL BioTherapeutics, Function Oncology, Ring Therapeutics, Chroma Medicine
Omega FundsSeries A LeadNew York: 9%, Waltham: 9%, Boston: 9%1170%1361Bicara Therapeutics, Chroma Medicine, NRG Therapeutics, Photys Therapeutics, CDR-Life
Nextech InvestSeries B LeadSan Diego: 21%, Cambridge: 14%, San Mateo: 7%1160%1293Flare Therapeutics, CARGO Therapeutics, Hexagon Bio, Alpha-9 Theranostics, Alterome Therapeutics
Pontifax FundSeries A Follow-onLyon: 11%, New York: 7%, Atlanta: 7%150%0161Adcendo, Amolyt Pharma, Anaveon, Emergence Therapeutics, Antios Therapeutics
Bill & Melinda Gates FoundationSeries B LeadCambridge: 25%, Boston: 8%, New York: 8%140%171Vedanta Biosciences, Smart Immune, Ensoma, Affinivax, Immunocore
Cambridge Innovation CapitalSeries A Follow-onCambridge, UK: 50%, Dublin: 12%, London: 12%100%161Complement Therapeutics, Mosaic Therapeutics, Carrick Therapeutics, Pretzel Therapeutics, Microbiotica
Colt VenturesSeries A LeadNewport Beach: 22%, Boston: 22%, Menlo Park: 22%120%040Alterome Therapeutics, Odyssey Therapeutics, Odyssey Therapeutics, ReCode Therapeutics, Erasca
First RoundSeed LeadSan Francisco: 33%, Palo Alto: 22%, Redwood City: 11%130%040Eigen Therapeutics, 64x Bio, Mythic Therapeutics, Reverie Labs, 64x Bio
Flerie InvestUndisclosed LeadLondon: 40%, Cambridge, UK: 20%, Jerusalem: 20%130%030Prokarium, Microbiotica, KAHR Medical, Amarna Therapeutics, Prokarium
DROIA Oncology VenturesSeries A LeadSouth San Francisco: 25%, New York: 19%, Cambridge: 19%140%180QurAlis, Volastra Therapeutics, Vicinitas Therapeutics, Ambagon Therapeutics, Frontier Medicines
Red Tree Venture CapitalSeries C Follow-onSan Mateo: 20%, Cambridge: 20%, Menlo Park: 20%120%031Bicara Therapeutics, CARGO Therapeutics, Alladapt Immunotherapeutics, Rondo Therapeutics, Pipeline Therapeutics
Schusterman Family InvestmentsSeries A LeadNew York: 50%, Boston: 50%120%020Ratio Therapeutics, Immunai
Alpha Wave GlobalSeries C Follow-onCambridge: 25%, San Diego: 25%, Berlin: 25%100%161LENZ Therapeutics, Alto Neuroscience, Apnimed, Apnimed, Amylyx Pharmaceuticals
Hatteras Venture PartnersSeries A Follow-onDurham: 13%, Cambridge, MA: 13%, New Haven: 13%120%0100Aer Therapeutics, Code Biotherapeutics, AN2 Therapeutics, Tune Therapeutics, Vigil Neuroscience
Duquesne Family OfficeSeries A LeadNew York: 50%, Boston: 50%120%020Ratio Therapeutics, Immunai
Brandon CapitalSeries A LeadWatertown: 11%, Menlo Park: 11%, Tel Aviv: 11%140%270Entact Bio, CatalYm, NRG Therapeutics, Pheon Therapeutics, Allay Therapeutics
Sante VenturesSeries A LeadBoston: 50%, Plymouth Meeting, PA: 25%, San Diego: 25%140%040Sensorium Therapeutics, Nirogy Therapeutics, Libra Therapeutics, Geneos Therapeutics
EarlyBird Venture CapitalSeries A Follow-onDublin: 33%, Lausanne: 33%, Oxford: 33%100%020Grey Wolf Therapeutics, Oculis, Priothera Limited
JJDCSeries A Follow-onSouth San Francisco: 12%, Boston: 12%, Lexington, MA: 6%150%2220Rapport Therapeutics, Perceive Biotherapeutics, SonoThera, Nucleome Therapeutics, Locus Biosciences
Parker InstituteSeries A LeadSouth San Francisco: 50%, Boston: 17%, Cambridge: 17%140%050Akamis Bio, ArsenalBio, Affini-T Therapeutics, ArsenalBio, Xyphos
Qatar Investment AuthoritySeries B Follow-onBoston: 27%, Cambridge: 18%, Basel: 9%100%1110Oricell, Ensoma, Sionna Therapeutics, Ventus Therapeutics, T-knife
Index VenturesN/ADelft: 100%100%010Cradle
GreatPoint VenturesSeries A Follow-onCambridge: 40%, New York: 20%, Boston: 20%100%030LinusBio, Odyssey Therapeutics, Glympse Bio, Glympse Bio, Skyhawk Therapeutics
UCBSeries A LeadLeuven: 22%, Sheffield: 11%, Cambridge: 11%150%080Switch Therapeutics, Code Biotherapeutics, Splice Bio, Neurona Therapeutics, ExeVir Bio
Novo SeedsSeries A LeadCopenhagen: 44%, Louvain-la-Neuve, Belgium: 11%, Aarhus, Denmark: 11%150%050Breye Therapeutics, Muna Therapeutics, Adcendo, IO Biotech, NorthSea Therapeutics
Asahi Kasei PharmaSeries B Follow-onSan Carlos: 40%, Tokyo: 20%, London: 20%100%040iVexSol, LUCA Science, Glycomine, Pulmocide, Glycomine
3E BioventuresSeries A LeadSan Diego: 23%, San Carlos: 15%, Shanghai: 15%130%180Eluminex, Lipidio Pharmaceuticals, Dewpoint Therapeutics, Alebund Pharmaceuticals, Cullgen
Bow CapitalN/ABerkeley: 67%, New York: 33%100%010LinusBio, GenEdit, GenEdit
AbingworthSeries A LeadBoston: 17%, : 12%, Cambridge: 8%1100%1180Pathalys Pharma, Entact Bio, Anjarium Biosciences, HilleVax, Wugen
Novartis Venture FundSeries A LeadCambridge: 17%, Boston: 13%, South San Francisco: 9%1130%2271Flare Therapeutics, Mediar Therapeutics, Mediar Therapeutics, CatalYm, Alto Neuroscience
ORI CapitalSeries C LeadIrvine: 60%, Natick: 20%, London: 20%130%030CG Oncology, AffyImmune, CG Oncology, CG Oncology, Orchard Therapeutics
Taiho PharmaceuticalSeries A Follow-onCambridge: 24%, Cambridge, MA: 12%, South San Francisco: 12%130%0120hC Bioscience, Normunity, Transition Bio, Parthenon Therapeutics, Axial Therapeutics
TPG BiotechSeries A Follow-onSouth San Francisco: 17%, Philadelphia: 17%, San Diego: 17%120%040Santa Ana Bio, ViaCyte, Carisma Therapeutics, Azura Ophthalmics, Neogene Therapeutics
SymBiosisSeries C LeadCambridge: 18%, Somerville, MA: 18%, Watertown: 9%140%081Metagenomi, Ensoma, SalioGen, PlateletBio, Vedanta Biosciences
Bristol MyersSeries B Follow-onCambridge: 26%, Copenhagen: 6%, Seattle: 6%150%3240TORL BioTherapeutics, Mediar Therapeutics, iVexSol, Cajal Neuroscience, Capstan Therapeutics
LongitudeSeries A LeadNew York: 7%, San Diego: 7%, Dublin: 7%1100%1171Alpha-9 Theranostics, CG Oncology, Zenas Biopharma, Rivus Pharmaceuticals, Endeavor BioMedicines
Alethea CapitalN/ASan Diego: 50%, La Jolla: 50%100%010Lipidio Pharmaceuticals, Avidity Biosciences
Catalys PacificSeries A LeadPhiladelphia: 33%, La Jolla: 17%, San Diego: 17%120%031Pathalys Pharma, Arialys Therapeutics, Mineralys Therapeutics, HilleVax, Mineralys Therapeutics
Cormorant Asset ManagementSeries B Follow-onCambridge: 16%, San Diego: 9%, South San Francisco: 8%110-50%2843OnKure, Chroma Medicine, CARGO Therapeutics, Garuda Therapeutics, Ensoma
Intermediate Capital GroupSeries B Follow-onRedmond, WA: 50%, San Diego: 25%, Lyon: 25%120%030Amolyt Pharma, Wugen, Eliem Therapeutics, Eliem Therapeutics
Amplitude VenturesSeries A Follow-onToronto: 22%, Vancouver: 22%, Menlo Park: 11%130%180Evommune, Abdera Therapeutics, Congruence Therapeutics, Gandeeva Therapeutics, Prilenia Therapeutics
MSD CapitalSeries D Follow-onSomerville, MA: 50%, London: 50%100%020Turbine, Finch Therapeutics
Deep Track CapitalSeries B Follow-onSouth San Francisco: 12%, Cambridge, MA: 12%, Cambridge: 12%100%3150TORL BioTherapeutics, Hemab, Apogee Therapeutics, Lusaris Therapeutics, Abivax
FidelitySeries C Follow-onCambridge: 18%, San Diego: 7%, South San Francisco, CA: 7%022-100%2630Apogee Therapeutics, Emalex Biosciences, Odyssey Therapeutics, Galvanize Therapeutics, Dianthus Therapeutics
DeerfieldSeries B Follow-onSouth San Francisco: 11%, Cambridge: 9%, San Diego: 7%017-100%0401Perceive Biotherapeutics, Innervace, Vicinitas Therapeutics, Apertura Gene Therapy, Aurion Biotech
F-Prime CapitalSeries A LeadLondon: 13%, Cambridge: 13%, Cambridge, MA: 9%016-100%1262Bicara Therapeutics, TandemAI, Ensoma, Neumora Therapeutics, Sironax
Innovation EndeavorsSeries A Follow-onSan Carlos: 14%, Palo Alto: 14%, Boston: 14%020%030Harmonic Discovery, Character Biosciences, GRO Biosciences, Eikon Therapeutics, BigHat Biosciences
Hummingbird VCSeries A Follow-onBoulder: 40%, New York: 20%, Menlo Park: 20%020%031Enveda Biosciences, Kaleidoscope, Kernal Biologics, BillionToOne, Enveda Biosciences

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